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Cancer Predisposition

November 8th - 11th, 2018

Chaired By

 John M. Maris, MD, University of Pennsylvania
 Judy E. Garber, MD, MPH, Harvard University

Important Dates

 Completed - Acceptance
 08/01/2018 - Travel Form )
 10/15/2018 - Abstracts )

Venue Information

Geneva National Resort
1221 Geneva National Avenue, South
Lake Geneva, WI 53147


Travel Agent Information

 Meeting #: Refer to your packet.
 Hours: 8:00am – 8:00 pm EST M-F
 Domestic: 669-210-8002
 International : 623-516-6140

About the Forbeck Foundation

 Forbeck Forum Information
 Travel Information
 General Program
 Frequently Asked Questions
 How to donate to this forum

Program Description

There has been an exponential increase in our discovery of heritable DNA variants that predispose to cancer, but we still have only a rudimentary understanding of the mechanistic underpinnings of cancer initiation and epistatic interactions. We also know that that cancer predisposing events shape the somatic genome, and that genetic, epigenetic and/or stochastic events often select for oncogenic drivers that initiate tumorigenesis. Finally, we have catalogued the majority of cancer predisposing mutations in protein coding genes, but are only at the beginning of understanding how both common and rare DNA variation in the noncoding genome influence malignant transformation and clonal evolution.

The 34th annual Forbeck Foundation meeting will bring together leaders in the field of cancer predisposition, with scientists having expertise in both pediatric and/or adult malignancies. We will review the landscape of what is known about cancer predisposition, but highlight current gaps including understanding polygenic risk and epistatic interaction at the cellular level. We will highlight ongoing efforts to understand the translatable lessons from large association studies on risk prediction and consider the implications of germline mutations for various mechanisms of therapeutic interventions, including immune modulation. We will ask questions such as: "How do we define the spectrum of tumors, adult and pediatric, associated with germline mutations?" and "How much heritability is yet to be discovered?". But we will also delve into cellular mechanisms of tumor initiation, as well as practical issues of variant curation and genetic counseling. Finally, we will attempt to define research priorities and short- and long-term milestones for the cancer predisposition field moving forward.

The 2018 Forum on Cancer Predisposition will be chaired by Dr. John Maris from the Children's Hospital of Philadelphia and the University of Pennsylvania, and Dr. Judy Garber from the Dana Farber Cancer Institute and Harvard Medical School. While we expect to explore mechanisms of cancer initiation in great depth, the meeting will also seek to focus on how research in the field of cancer predisposition should impact patient care now and in the future.

Participant Information

Participant Institution
Kristopher Bosse, MD Children's Hospital of Philadelphia
Vivian Chang, MD Univeristy of California Los Angeles
Stephen Chanock, MD National Cancer Institute
Olivier DeLattre, Institut Curie
Douglas Easton, PhD University of Cambridge
William Foulkes, PhD, M.B.B.S., B.Sc. McGill University
Judy Garber, MD, MPH Dana-Farber Cancer Institute
Elizabeth Jaffee, MD Johns Hopkins University
Junne Kamihara, MD, PhD Dana-Farber Cancer Institute
Allison W. Kurian, MD, M.Sc. Stanford University
Mignon Loh, UCSF Benioff Children's Hospital
David Malkin, MD, FRCPC The Hospital for Sick Children
John Maris, MD Children's Hospital of Philadelphia
Yael Mosse, MD Children's Hospital of Philadelphia
Kenneth Offit, MD Memorial Sloan Kettering Cancer Center
Olopade Olufunmilayo, MD University of Chicago
Sharon Plon, MD, PhD Baylor College of Medicine
Daniela Robles-Espinoza, PhD Nat'l University of Mexico
Joshua B. Rubin, MD, PhD Washington University
Uri Tabori, MD The Hospital for Sick Children

Airport Information

Milwaukee's General Mitchell International Airport (MKE) is the preferred airport as it is only 45 minutes from the meeting location.

  • Arrivals - Thursday at 1 PM, 3 PM and 6 PM
  • Departures - Sunday at 10 AM and 12 PM

Chicago's O'Hare Airport (ORD) is 1 1/2 hours from the meeting location without traffic. The Foundation can only accommodate 1 pick up per day at O'Hare. If you absolutely must fly into O'Hare (ie: International Flights) the Foundation will have the following pick up times at O'Hare:

  • Arrivals - Thursday at 3 PM
  • Departures - Sunday at 10 AM

Any other arrival times at Chicago's O'Hare airport must be arranged and paid for by the individual. You are welcome to arrive on Wednesday.


The abstracts should be only one or two paragraphs outlining the theme of your presentation and should reflect the objective and spirit of the meeting (see above). Abstracts will be circulated about one week before the meeting. The meeting organizer will start requesting them a month before the meeting.