RNA Modifications in mRNA Translation and Cancer
Forum Chairs
Forum Description
Cancer cells must continuously manufacture proteins in response to their cellular needs and environment to proliferate, adapt to stresses, and metastasize to different organs. mRNA translation is a fundamental process that relies on several well-ordered reactions. The ribosome, with the help of transfer RNAs (tRNAs), and multiple RNA binding proteins, translates the genetic code in mRNA to build specific proteins. Because mRNA translation is required to make proteins for all cells, the therapeutic potential of targeting mRNA translational processes in cancer was believed to be limited. Recent studies have found that cancer cells (e.g. breast, melanoma, leukemia, pancreas) are dependent on specific RNA modifying pathways that regulate mRNA translation during growth, metastasis and adaptation to the tumor environment. These findings have reinvigorated efforts in identifying therapeutic vulnerabilities against mRNA translation-dependencies in cancers. Here, we propose to organize a Focus Meeting to bring together current and emerging leading scientists and clinicians to discuss recent advances in the field, to explore potential novel areas for therapeutic intervention for patients, and to identify important future directions.
RNA modifications have been shown to be important epitranscriptomic regulators in cancer, however mechanisms of RNA modification that drive disease progression remain an under-explored area. Although major efforts have been made to understand how specific modifications of mRNAs, tRNAs and rRNAs contribute to regulation of translation, this knowledge has yet to be translated into the clinic. Recent reports have shown a specific role for individual tRNAs and mRNA modifications in a few cancer models, yet the global role of diverse RNA modifications in cancer is largely unknown. For this reason, the forum topic “ RNA modifications in mRNA translation and Cancer” is both highly relevant and novel. It highlights an emerging field that has the potential to have significant implications in developing cancer therapy.
GOALS OF THIS FORUM
The aim of the meeting is to bring together scientists with diverse expertise in different aspects of mRNA translation, tRNA and ribosomal biology and RNA modification. The goal is to combine biochemical and technological insights with expertise in cancer biology to identify outstanding questions in the field as well as new mechanisms of RNA modification that can be targeted therapeutically.
Forum Summary
Venue & Travel Information
Travel Forms
Travel forms are due 30 days prior to the start of the forum to allow enough time to plan transportation.
To help reduce transportation costs, the Foundation tries to group travelers on shuttle vans rather than providing transportation for single travelers.
The Aspen Airport (ASE) is the preferred airport as it is only 10 minutes from the venue.
We cannot provide shuttle transportation to or from Denver.
- Arrival day of the forum at approximately 1:00 PM, 3:00 PM and 5:00 PM
- Departures from the venue at approximately 10:00 AM and 12:00 PM
Travel Policy
Please familiarize yourself with our policies and procedures for travel. We truly appreciate you taking the time to participate in this forum. As you make your plans, please remember that we are a nonprofit organization dependent on donations and volunteers. We do NOT pay for upgrades, change fees, incurred costs resulting from a flight change, transportation to or from your local (home side) airport, meals or other incidentals.
- Travel Confirmation will be sent out within 1 week of the forum. This will include a hotel confirmation number, if there is one, and airport transfer details. We have to wait until we receive almost everyone’s travel to book airport transfer. Due to frequent airline changes, we wait until the week of the forum to send this out.
- Airport transfer is provided by Foundation staff, volunteers or arranged shuttle at specific times. If you opt to utilize Foundation airport transportation on your travel form, please be patient in receiving this information. We will send it to the week of the forum.
- Speaker agenda is not sent out prior to the forum. It will be provided upon arrival in the forum packet. We do not tell people when they are speaking because we expect everyone to attend all sessions. Sessions are all day Friday and Saturday.
- REMINDER: We do not reimburse for home side airport transfer or incidentals while traveling. We will not honor miscellaneous receipts sent for these expenses.
- Spouses are welcome to come with you at their own cost but are not allowed to attend the forum. Please no children.
What the Foundation Pays
Accommodations and meals are provided by the foundation during the forum. Airfare will be covered only if booked in accordance with our policy and only up to the amount in which you were approved for. The Foundation will also cover airport transportation on the forum side at the designated shuttle times. You can select not to utilize Foundation arranged transportation at your own expense when completing the travel form. Once your travel form is received your accommodations and airport transfer will be confirmed. Please let us know of any food allergies or other information we should be aware of on the travel forms.
- Note we do not cover upgrades, changes, late bookings, etc.
- Flights must be booked at least 30 days prior to the forum to confirm your accommodations and airport transfer.
- As a nonprofit we utilize volunteers and other methods to maximize our efforts (or our donor support) when making accommodations and arranging ground transportation. Ground transportation will be provided upon your arrival either by a foundation volunteer or arranged shuttle. You will be provided airport transportation information the week of the forum. We do not reimburse for home side airport transfer or incidentals while traveling.
Abstracts
Abstracts are due 30 days prior to the start of the meeting to allow enough time to prepare the meeting book.
The abstracts should be only one or two paragraphs outlining the theme of your presentation and should reflect the objective and spirit of the meeting (see above). Abstracts will be circulated about one week before the meeting. The meeting organizer will start requesting them a month before the meeting.
Forum Structure
The structure of the forum has been developed over years of experience.
- Participants have approximately 45 minutes, depending on the number of participants, for their presentation and discussion. The presentation is meant as a conversation start and should last about twenty minutes briefly covering background information and areas that are new or need further input. This should be structured in such a way as to lead to a lively discussion. Participants are encouraged to interrupt to ask questions or start discussions.
- A MAXIMUM of 2 slide equivalents per presentation is allowed (Power point slides should not contain more than one graph or gel per slide and no more than 5 bullet points to stress the points being made by the presenter.) We appreciate cooperation with the spirit of this guideline. Handouts are welcome but should be distributed before sessions.
- Everyone is expected to actively participate in every session and discussions.
- The time spent at the forum is relatively short, so please be familiar with papers received prior to arrival.
- It is very important that you commit to all sessions of the 2 days of the forum.
Forbeck Scholars Participation
Scholars are selected for each Forbeck Forum. These are outstanding junior clinical or post-doctoral fellows selected based on the quality and relevance of science.
- Scholars present for 30-45 minutes, depending on the number of participants
- The same presentation rules apply for scholars
- After the Forum you are selected to attend, you will attend three years of Scholar Retreats held in Lake Geneva, WI. If you attend a Fall Forum, you will attend the Spring Retreat. If you attend a Spring Forum you will attend a Fall Retreat.
- Scholars are selected by the Foundation Scientific Advisory Board and peer reviewers selected from past Forbeck Scholars.
General Program
The outline below illustrates a typical program schedule. You will receive a complete schedule, including speaking times, the Thursday the forum starts.
Frequently Asked Questions
Below are some of our most Frequently Asked Questions. If you have something new to ask, please feel free to contact us.
- Travel Confirmation will be sent out within 1 week of the forum. This will include a hotel confirmation number, if there is one, and airport transfer details. We have to wait until we receive almost everyone’s travel to book airport transfer. Due to frequent airline changes, we wait until the week of the meeting to send this out.
- Airport transfer is provided by Foundation staff, volunteers or arranged shuttle at specific times. If you opt to utilize Foundation airport transportation on your travel form, please be patient in receiving this information. We will send it to the week of the forum.
- Speaker agenda is not sent out prior to the meeting. It will be provided upon arrival in the meeting packet. We do not tell people when they are speaking because we expect everyone to attend all sessions. Sessions are all day.
- Frequently airport transfer is provided by volunteers. Please be patient on receiving this information. Airport transfer will be sent out prior to arrival.
- REMINDER: We do not reimburse for home side airport transfer or incidentals while traveling. We will not honor miscellaneous receipts sent for these expenses.